Researchers discover why exercise is good and high blood pressure is bad for the heart

When heart under stress during exercise is considered healthy. Yet stress due to hypertension is bad for the heart.

Why?

The researchers examined a chain of metabolic processes in the heart that has an epigenetic switch called histonedeacetylase 4 (HDAC4) at its outset. The newly discovered signal transmission pathway can be up regulated or down regulated in mouse hearts depending on the stress. The researchers identified this because at the end of the signal pathway, a fragment of HDAC4 is more prevalent in healthy mouse hearts after physiological stress, the mouse hearts that were subjected to pathological stress did not generate this fragment.

The researchers aimed to investigate the effect more deliberately and produced genetically modified mice that are not able to generate the HDAC4 fragment. The animals were subjected to physiological stress and, surprisingly, exercise no longer had the healthy effect on them. Instead, they developed Temporary heart failure after the intensive workout which led to a distinctly reduced performance. This heart failure, however, regressed again.
Reasearchers states that this is because it can only be detected if the cardiac function is examined during or in the minutes immediately after exercise.
The fragment called HDAC4 has capability to protect the heart from damage caused by temporary physiological stress. During exercise, there are frequently rest periods for the heart. An enzyme, proteinkinase A recovers during these periods and then ensures that the healthy path via the activation of the HDAC4 fragment is followed at a crossroads of the metabolic chain.

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